Thin Films Seminar
Friday, November 18, 2005, 9:30am
Damir B. Khismatullin (Duke University, Biomedical Engineering)
Towards a computational model of leukocyte adhesion cascade: Leukocyte rolling
Abstract:- Recruitment of leukocytes into sites of acute and chronic
inflammation is a vital component of the innate immune response in humans
and plays an important role in cardiovascular diseases, such as
ischemia-reperfusion injury and atherosclerosis. Leukocytes extravasate into the inflamed tissue through a multi-step process called "leukocyte adhesion
cascade", which involves initial contact of a leukocyte with activated
endothelium (tethering), leukocyte rolling, firm adhesion, andtransendothelial migration. Recently we developed a fully three-dimensional
CFD model of receptor-mediated leukocyte adhesion to endothelium in a
parallel-plate flow chamber. The model treats the leukocyte as a
viscoelastic cell with the nucleus located in the intracellular space and
cylindrical microvilli distributed over the cell membrane.
Leukocyte-endothelial adhesion is assumed to be mediated by adhesion
molecules expressed on the tips of cell microvilli and on endothelium. We
show that the model can predict both shape changes and velocities of rolling
leukocytes under physiological flow conditions. Results of this study also
indicate that viscosity of the cytoplasm is a critical parameter of
leukocyte adhesion, affecting the cell's ability to roll on endothelium.
This work is supported by NIH Grant HL- 57446 and NCSA Grant BCS040006 and
utilized the NCSA IBM p690.
[In the end of my talk, I will show my recent results on simulating mucus
transport in airways.]
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