Math 214: Modeling of Biological Systems Instructor: J. Harer This course will focus on the mathematics of gene regulatory networks. We will discuss a variety of network models, including discrete models, ordinary differential equation models and stochastic differential equation models. We will also study how networks are inferred from experimental data and how both analysis and simulation of models can inform biological experiments. The course will be a mixture of lectures by the professor, group presentations by students and a major final project by each student. Projects will be set up at the start of the semester, and will be based on student interest, but must focus on the determination and analysis of a particular regulatory network. A final paper and a one-hour presentation will be required of each student. Grades will be based on class participation, work in groups and the final project. There will be no exams. Prerequisites: Students should have some facility with differential equations, although all necessary material will be reviewed in the class. Some basic knowledge of cell biology is also recommended. Students uncertain about their background should consult the professor in advance.